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In addition, dual incretin agonists (e.g., GIP/GLP-1 co-agonists such as tirzepatide) have expanded this therapeutic space, while other long-acting or multi-agonist candidates remain investigational ( This review provides a structured overview of how GLP-1 RAs impact gut microbiota composition and function, drawing on recent human clinical studies and mechanistic animal models

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However, the pathological skin thickening in psoriasis hampers the penetration of macromolecules administered using IP